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Defective interfering genomes and Ebola virus persistence

In: 
The Lancet
Art der Veröffentlichung: 
Art des Artikels: 
andere Autoren: 
Laurent Roux, Daniel Kolakofsky
Erscheinungsdatum: 
2016
Edition: 
Vol. 388, No. 10045, pp. 659–660

Michael Jacobs and colleagues (The Lancet, 2016, Vol. 388, p. 498-503) provide clinical and virological evidence of a relapse of Ebola virus disease (EVD) presenting as acute meningo-encephalitis 9 months after recovery from an acute infection. However exceptional, this case adds to an increasing number of reports suggesting that Ebola virus can persist for months in immune-privileged anatomical sites, such as semen, ocular tissues, breastmilk, and the central nervous system. In such cases, unknown immunological dysfunctions certainly play a part in delaying the clearance of Ebola-infected cells.